충치예방과 관련된 천연물(natural products) 연구의 현황
Natural Product Research in Dental Caries Prevention
전재규,
소속 상세정보
전재규 ( Jeon Jae-Gyu ) - 전북대학교 치의학전문대학원 예방치학교실
KMID : 0362720120500090544
Abstract
Dental caries is a biofilm-related oral disease, and continues to afflict the majority of the world? population. Although fluoride, delivered in various modalities, remains the mainstay for the prevention of caries, additional approaches are required to enhance its effectiveness. Natural products have been used as a major source of innovative and effective therapeutic agents throughout human history, and have shown promise as a source of components for the development of new drugs. In addition, studies using natural products to prevent or treat oral diseases such as dental caries have received a great deal of attention. A number of compounds, such as epicatechin, allicin and sanguinarine, isolated from natural products, have also been investigated for their efficacy against oral microbial pathogens. However, the use of natural products as an anti-caries agent in clinical practice was controversial because of inadequate knowledge concerning their mechanisms of action and chemical characterization. This study focuses on the current knowledge of natural products in dental caries prevention and suggests natural products are importance sources for the prevention of dental caries.
키워드
Dental Caries; Dental biofilms; Natural Products; Virulence Factors
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